PUBLICATIONS
| 2025 | |
|---|---|
| 39 | 39. G. Yan†, M. Pan†, A. G. Santiago, A. Keller, M. Lofgren, R. Banerjee, P. Chen*, T.-Y. Chen*
"Conformation-Gated Binding Drives Negative Cooperativity in ATP:cob(I)alamin Adenosyltransferase for Optimized Cobalamin Handling." bioRxiv, 2025, , . [pdf] |
| 38 | M.-H. Wen†, H. Chen†, G. Yan†, Y. Zhang, W. Chen, M. V. Dokholyan, J. Wang, N. V. Dokholyan, T.-Y. Chen*
"Transporter De-oligomerization Regulates Copper Uptake into Human Cells." Research Square, 2025, , , . [pdf] |
| 37 | R. D. Jana, H. D. Nguyen, G. Yan, T.-Y. Chen, Loi H. Do*
"Reversing Signs of Parkinsonism in a Cell Model Using Mitochondria-Targeted Organoiridium Catalysis." J. Med. Chem., 2025, accepted, 2, 514–520. [pdf] |
| 2024 | |
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| 36 | J.-X. Cheng*, T.-Y Chen*, P. Chen*
"The Evolution of Subdiffraction Chemical Imaging from Nanoscale to AI." Chem. Biomed. Imaging, 2024, 2, 11, 731–732. [pdf] |
| 35 | J. Won*, T.-Y. Chen, A. G. Santiago, P. Chen*
"Memory Effects of Transcription Regulator-DNA Interactions in Bacteria." Proc. Natl. Acad. Sci. U.S.A, 2024, 121, e2407647121. [pdf] |
| 34 | H. Chen†, G. Yan†, M.-H. Wen†, K. N. Brooks, Y. Zhang, P.-S. Huang, T.-Y. Chen*
"Advancements and Practical Considerations for Biophysical Research: Navigating the Challenges and Future of Super-resolution Microscopy." Chem. Biomed. Imaging, 2024, 2, 5, 331–344. [pdf] |
| 33 | G. Yan†, Y. Zhang†, A. Allamprese†, K. N. Brooks, W. Chen, S. Yan, T.-Y. Chen*
"From Molecules to Classrooms: A Comprehensive Guide to Single-Molecule Localization Microscopy." J. Chem. Educ., 2024, 101, 2, 514–520. [pdf] |
| 2023 | |
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| 32 | H. Chen, T.-Y. Chen*
"From Monomers to Hexamers: A Theoretical Probability of the Neighbor Density Approach to Dissect Protein Oligomerization in Cells." Ana. Chem., 2023, 96, 2, 895–903. [pdf] |
| 31 | D. Nguyen† G. Yan†, T.-Y. Chen*, L. H. Do* *
"Variations in Intracellular Organometallic Reaction Frequency Captured by Super Resolution Fluorescence Microscopy." Angew. Chem. Int. Ed., 2023, 135, 31, e202300467. [pdf] |
| 30 | H. Chen, T.-Y. Chen*
"Probing Oxidant Effects on Superoxide Dismutase 1 (SOD1) Oligomers in Live Cells Using Single-Molecule Fluorescence Anisotropy." Chem. Biomed. Imaging, 2023, 1, 49–57. [pdf] |
| 29 | M. Zulkifli, A. N. Spelbring, Y. Zhang, S. Soma, S. Chen, L. Li, T. Le, V. Shanbhag, M. J. Petris, T.-Y. Chen, M. Ralle, D. P. Barondeau, V. M. Gohil*
"FDX1-Dependent and -Independent Mechanisms of Elesclomol-Mediated Intracellular Copper Delivery." Proc. Natl. Acad. Sci. U.S.A., 2023, 120, e2216722120. [pdf] |
| 2022 | |
|---|---|
| 28 | Y. Zhang, M.-H. Wen, G. Qin, C. Cai, and T.-Y. Chen*
"Subcellular Redox Responses Reveal Different Cu-dependent Antioxidant Defenses between Mitochondria and Cytosol." Metallomics,2022, 143, mfac087. [pdf] |
| 27 | Y.-H. Chen, P.-S. Huang, M. Pan, M.-H. Wen, D.-F. Lee, , and T.-Y. Chen*
"Cu Induces CTR1 Endocytosis through Modulating CTR1 Oligomer States." Stem Cell Res.2022, 63, 102845. [pdf] |
| 2021 | |
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| 26 | M.-H. Wen†, X. Xie†, P.-S. Huang, K. Yang, and T.-Y. Chen*
"Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system." Open Biology2021, 11, 210128. [pdf] |
| 25 | P.-S. Huang, M.-H. Wen, X. Xie, A. Xu, D.-F. Leeb, T.-Y. Chen*
"Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1." Stem Cell Res., 2021, 54, 102415. [pdf] |
| 2020 | |
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| 24 | H. Chen†, X. Xie†, T.-Y. Chen*
"Single-Molecule Microscopy for In-Cell Quantification of Protein Oligomeric Stoichiometry." Curr. Opin. Struct. Biol., 2020, 66, 112-118. †: Co-first authors. [pdf] |
| 23 | M. Pan, Y. Zhang, G. Yan, T.-Y. Chen*
"Dissection of interaction kinetics through single-molecule interaction simulation." Anal. Chem., 2020, 92, 11582-11589. [pdf][SI] |
| 2019 | |
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| 22 | M.-H. Wen, X. Xie, J. Tu, D.-F. Lee, T.-Y. Chen*
"Generation of a genetically modified human embryonic stem cell expressing fluorescence tagged ATOX1." Stem Cell Res., 2019, 41, 101631. [pdf] |
| 2018 | |
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| 21 | X. Xie†, Y.-S. Cheng†, M.-H. Wen, A. Calindi, K. Yang, C.-W. Chiu, T.-Y. Chen*
"Quantifying the Oligomeric States of Membrane Proteins in Cells through Super-resolution Localizations." J. Phys.Chem. B 2018, 122(46), 10496-10504. †: Co-first authors. [pdf][SI] |
| 20 | T.-Y. Chen*, Y.-S. Cheng, P.-S. Huang, P. Chen*
"Facilitated unbinding via multivalency-enabled ternary complexes: New paradigm for protein-DNA interactions." Acc. Chem. Res., 2018, 51, 860-868. [pdf] |
| 2017 | |
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| 19 | A. G. Santiago†, T.-Y. Chen†, L. A. Genova, W. Jung, A. M. G. Thompason, M. M. McEvoy, P. Chen*
"Adaptor Protein Mediates Dynamic Pump Assembly for Bacterial Metal Efflux." Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 6694-6699. †: Co-first authors. [pdf][SI] |
| 2016 | |
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| 18 | F. Yang, T.-Y. Chen, Ł. Krzemiński, A. G. Santiago, W. Jung, P. Chen.
"Single-Molecule Dynamics of the Molecular Chaperone Trigger Factor in Living Cells." Mol. Microbiol., 2016, 102, 992-1003. [pdf][SI] |
| 17 | J. B. Sambur, T.-Y. Chen, E. Choudhary, G. Chen, E. J. Nissen, E. M. Thomas, N. Zou, P. Chen.
"Sub-particle reaction and photocurrent mapping to optimize catalyst-modified photoanodes." Nature, 2016, 530, 77-80. [pdf][SI] |
| 2015 | |
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| 16 | T.-Y. Chen†, W. Jung†, A. G. Santiago, F. Yang, Ł. Krzemiński, P. Chen.
"Quantifying Multi-State Cytoplasmic Molecular Diffusion in Living Cells via Inverse Transform of Confined Displacement Distribution." J. Phys. Chem. B, 2015 , 119, 14451-14459. †: Co-first authors. [pdf][SI] |
| 15 | D. J. Martell, C. P. Joshi, A. Gaballa, A. G. Santiago, T-Y. Chen, W. Jung, J. D. Helmann, P. Chen.
"Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription." Proc. Natl. Acad. Sci. U.S.A., 2015, 112, 13467-13472. [pdf] [SI] |
| 14 | T.-Y. Chen†, A. G. Santiago†, W. Jung, Ł. Krzemiński, F. Yang, D. J. Martell, J. D. Helmann, P. Chen.
"Concentration- and Chromosome-Organization-dependent Regulator Unbinding from DNA for Transcription Regulation in Living Cells." Nat. Commun., 2015, 6, 7445. DOI: 10.1038/ncomms8445. †: Co-first authors. [pdf] [SI] News highlight: • "How Transcription Factors Depart Their Targets In Cells," Chemical & Engineering News, 2015, 93, 25. • "Research finds protein regulation linked to cells' growth cycle", Cornell Chronicle, July 2015. |
| 2013 | |
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| 13 | P. Chen, A. M. Keller, C. P. Joshi, D. J. Martell, N. M. Andoy, J. J. Benítez, T.-Y. Chen, A. G. Santiago, F. Yang.
"Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones." Biochemistry, 2013, 52, 7170-7183. [pdf] |
| 12 | S. Maiti, H.-Y. Chen, T.-Y. Chen, C. -H. Hsia, D. H. Son. "Effect of Surfactant and Solvent on Spin-Lattice Relaxation Dynamics of Magnetic Nanocrystals." J. Phys. Chem. B, 2013, 117 (16), 4399-4405. [pdf] |
| 2012 | |
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| 11 | C. P. Joshi, D. Panda, D. J. Martell, N. M. Andoy, T. -Y. Chen, A. Gaballa, J. D. Helmann, P. Chen.
"Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator." Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 15121-15126. [pdf] [SI] |
| 10 | M. Keller, J. Benitez, D. Klarin, L. Zhong, M. Goldfogel, F. Yang, T.-Y. Chen, P. Chen. "Dynamic Multi-Body Protein Interactions Suggest Versatile Pathways for Copper Trafficking." J. Am. Chem. Soc., 2012, 134 (21), 8934-8943. [pdf] [SI] |
| 2011 | |
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| 9 | H.-Y. Chen, T.-Y. Chen, E. Berdugo, Y. Park, K. Lovering, D. H. Son.
"Hot Electron from Consecutive Exciton-Mn Energy Transfer in Mn-Doped Semiconductor Nanocrystals." J. Phys. Chem. C, 2011, 115, 11407-11412. [pdf] |
| 2010 | |
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| 8 | T.-Y. Chen, C.-H. Hsia, H.-Y. Chen, D. H. Son.
"Dynamics of Spin-Lattice Relaxation in CoxFe3-xO4 Nanocrystals." Ultrafast Phenomena XVII, 2010, 152-153. |
| 7 | T.-Y. Chen, C.-H. Hsia, H.-Y. Chen, D. H. Son.
"Size Effect on Chemical Tuning of Spin-Lattice Relaxation Dynamics in Superparamagnetic Nanocrystals." J. Phys. Chem. C, 2010, 114, 9713-9719. [pdf] |
| 6 | H.-Y. Chen, T.-Y. Chen, D. H. Son.
"Measurement of Energy Transfer Time in Colloidal Mn-Doped Semiconductor Nanocrystals." J. Phys. Chem. C, 2010, 114, 4418-4423. [pdf] |
| 2009 | |
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| 5 | C.-H. Hsia, T.-Y. Chen, D. H. Son.
"Time-Resolved Study on Surface Spin Effect on Spin-lattice Relaxation in Fe3O4 nanocrystals." J. Am. Chem. Soc., 2009, 131, 9146-9147. [pdf] |
| 2008 | |
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| 4 | T.-Y. Chen, C.-H. Hsia, D. H. Son.
"Time-Dependent Elastic Properties and Lattice Temperature of the Photoexcited Iron Oxide Nanocrystals." J. Phys. Chem. C, 2008, 112, 10125-10129. [pdf] |
| 3 | C.-H. Hsia, T.-Y. Chen, D. H. Son.
"Size-Dependent Ultrafast Magnetization Dynamic in Iron Oxide Nanocrystals." Nano Lett., 2008, 8 (2), 571-576. [pdf] |
| 2007 | |
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| 2 | T.-Y. Chen, C.-H. Hsia, H. S. Son, D. H. Son.
"Ultrafast Energy Transfer and Strong Dynamic non-Condon Effect on Ligand Field Transitions by Coherent Phonon in g -Fe2O3 Nanocrystals." J. Am. Chem. Soc., 2007, 129, 10829-10836. [pdf] |
| 2004 | |
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| 1 | 1. C.-H. Lin, T.-Y. Chen, C.-H. Cheng.
"Recent Development in Organic Light-Emitting Display." Instrum. Today, 2004, 26, 38-45. |