PUBLICATIONS

UH stadium
2021
25 M.-H. Wen, X. Xie, P.-S. Huang, K. Yang, and T.-Y. Chen* "Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system"
Under revision
24 P.-S. Huang, M.-H. Wen, X. Xie, A. Xu, D.-F. Leeb, T.-Y. Chen* "Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1"
Stem Cell Res., 2021, 54, 102415. [pdf]
2020
23 H. Chen, X. Xie, T.-Y. Chen* "Single-Molecule Microscopy for In-Cell Quantification of Protein Oligomeric Stoichiometry"
Curr. Opin. Struct. Biol., 2020, 66, 112-118. : Co-first authors. [pdf]
22 M. Pan, Y. Zhang, G. Yan, T.-Y. Chen* "Dissection of interaction kinetics through single-molecule interaction simulation”. Analytical Chemistry"
Anal. Chem., 2020, 92, 11582-11589. [pdf][SI]
2019
21 M.-H. Wen, X. Xie, J. Tu, D.-F. Lee, T.-Y. Chen* "Generation of a genetically modified human embryonic stem cell expressing fluorescence tagged ATOX1"
Stem Cell Res., 2019, 41, 101631. [pdf]
2018
20 X. Xie, Y.-S. Cheng, M.-H. Wen, A. Calindi, K. Yang, C.-W. Chiu, T.-Y. Chen* "Quantifying the Oligomeric States of Membrane Proteins in Cells through Super-resolution Localizations"
J. Phys.Chem. B 2018, 122(46), 10496-10504. : Co-first authors. [pdf][SI]
19 T.-Y. Chen*, Y.-S. Cheng, P.-S. Huang, P. Chen* "Facilitated unbinding via multivalency-enabled ternary complexes: New paradigm for protein-DNA interactions"
Acc. Chem. Res., 2018, 51, 860-868. [pdf]
2017
18 A. G. Santiago, T.-Y. Chen, L. A. Genova, W. Jung, A. M. G. Thompason, M. M. McEvoy, P. Chen. “Adaptor Protein Mediates Dynamic Pump Assembly for Bacterial Metal Efflux”.
Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 6694-6699. : Co-first authors. [pdf][SI]
2016
17 F. Yang, T.-Y. Chen, Ł. Krzemiński, A. G. Santiago, W. Jung, P. Chen. “Single-Molecule Dynamics of the Molecular Chaperone Trigger Factor in Living Cells”.
Mol. Microbiol., 2016, 102, 992-1003. [pdf][SI]
16 J. B. Sambur, T.-Y. Chen, E. Choudhary, G. Chen, E. J. Nissen, E. M. Thomas, N. Zou, P. Chen. “Sub-particle reaction and photocurrent mapping to optimize catalyst-modified photoanodes”.
Nature, 2016, 530, 77-80. [pdf][SI]
2015
15 T.-Y. Chen, W. Jung, A. G. Santiago, F. Yang, Ł. Krzemiński, P. Chen. “Quantifying Multi-State Cytoplasmic Molecular Diffusion in Living Cells via Inverse Transform of Confined Displacement Distribution”.
J. Phys. Chem. B, 2015 , 119, 14451-14459. : Co-first authors. [pdf][SI]
14 D. J. Martell, C. P. Joshi, A. Gaballa, A. G. Santiago, T-Y. Chen, W. Jung, J. D. Helmann, P. Chen. “Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription”.
Proc. Natl. Acad. Sci. U.S.A., 2015, 112, 13467-13472. [pdf] [SI]
13 T.-Y. Chen, A. G. Santiago, W. Jung, Ł. Krzemiński, F. Yang, D. J. Martell, J. D. Helmann, P. Chen. “Concentration- and Chromosome-Organization-dependent Regulator Unbinding from DNA for Transcription Regulation in Living Cells”.
Nat. Commun., 2015, 6, 7445. DOI: 10.1038/ncomms8445. : Co-first authors. [pdf] [SI]
News highlight:
• "How Transcription Factors Depart Their Targets In Cells," Chemical & Engineering News, 2015, 93, 25.
• "Research finds protein regulation linked to cells' growth cycle", Cornell Chronicle, July 2015.
2013
12 P. Chen, A. M. Keller, C. P. Joshi, D. J. Martell, N. M. Andoy, J. J. Benítez, T.-Y. Chen, A. G. Santiago, F. Yang. Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones.
Biochemistry, 2013, 52, 7170-7183. [pdf]
11 S. Maiti, H.-Y. Chen, T.-Y. Chen, C. -H. Hsia, D. H. Son.
Effect of Surfactant and Solvent on Spin-Lattice Relaxation Dynamics of Magnetic Nanocrystals.
J. Phys. Chem. B, 2013, 117 (16), 4399-4405. [pdf]
2012
10 C. P. Joshi, D. Panda, D. J. Martell, N. M. Andoy, T. -Y. Chen, A. Gaballa, J. D. Helmann, P. Chen. Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator.
Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 15121-15126. [pdf] [SI]
9 M. Keller, J. Benitez, D. Klarin, L. Zhong, M. Goldfogel, F. Yang, T.-Y. Chen, P. Chen.
Dynamic Multi-Body Protein Interactions Suggest Versatile Pathways for Copper Trafficking.
J. Am. Chem. Soc., 2012, 134 (21), 8934-8943. [pdf] [SI]
2011
8 H.-Y. Chen, T.-Y. Chen, E. Berdugo, Y. Park, K. Lovering, D. H. Son. Hot Electron from Consecutive Exciton-Mn Energy Transfer in Mn-Doped Semiconductor Nanocrystals.
J. Phys. Chem. C, 2011, 115, 11407-11412. [pdf]
2010
7 T.-Y. Chen, C.-H. Hsia, H.-Y. Chen, D. H. Son. Dynamics of Spin-Lattice Relaxation in CoxFe3-xO4 Nanocrystals.
Ultrafast Phenomena XVII, 2010, 152-153.
6 T.-Y. Chen, C.-H. Hsia, H.-Y. Chen, D. H. Son. Size Effect on Chemical Tuning of Spin-Lattice Relaxation Dynamics in Superparamagnetic Nanocrystals.
J. Phys. Chem. C, 2010, 114, 9713-9719. [pdf]
5 H.-Y. Chen, T.-Y. Chen, D. H. Son. Measurement of Energy Transfer Time in Colloidal Mn-Doped Semiconductor Nanocrystals.
 J. Phys. Chem. C, 2010, 114, 4418-4423. [pdf]
2009
4 C.-H. Hsia, T.-Y. Chen, D. H. Son. Time-Resolved Study on Surface Spin Effect on Spin-lattice Relaxation in Fe3O4 nanocrystals;.
J. Am. Chem. Soc., 2009, 131, 9146-9147. [pdf]
2008
3 T.-Y. Chen, C.-H. Hsia, D. H. Son. Time-Dependent Elastic Properties and Lattice Temperature of the Photoexcited Iron Oxide Nanocrystals;.
J. Phys. Chem. C, 2008, 112, 10125-10129. [pdf]
2 C.-H. Hsia, T.-Y. Chen, D. H. Son. Size-Dependent Ultrafast Magnetization Dynamic in Iron Oxide Nanocrystals.
Nano Lett., 2008, 8 (2), 571-576. [pdf]
2007
1 T.-Y. Chen, C.-H. Hsia, H. S. Son, D. H. Son. Ultrafast Energy Transfer and Strong Dynamic non-Condon Effect on Ligand Field Transitions by Coherent Phonon in g -Fe2O3 Nanocrystals.
J. Am. Chem. Soc., 2007, 129, 10829-10836. [pdf]